Water → N-1,2-Benzisoxazol-3-yl-4-[3-(4-chlorophenyl)-1,2,4-thiadiazol-5-yl]piperazine-1-carboxamide

関与物質

反応手順

To a solution of 5-chloro-3-(4-chlorophenyl)-1,2,4-thiadiazole (179 mg, 0.555 mmol) and N-1,2-benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate (200 mg, 0.555 mmol) in dimethylformamide (2 ml) was added triethylamine (0.389 ml, 2.78 mmol) at room temperature, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was poured to water, and the precipitated solid was separated by filtration, which was recrystallized from a mixed solvent of ethyl acetate and tetrahydrofuran to give 85.0 mg (34.7%) of the desired product.

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