Water → N-1,2-Benzisoxazol-3-yl-4-{3-[4-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl}piperazine-1-carboxamide

Participants

Reaction Steps

To a solution of 5-chloro-3-(4-trifluoromethylphenyl)-1,2,4-thiadiazole (147 mg, 0.555 mmol) and N-1,2-benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate (200 mg, 0.555 mmol) in N,N-dimethylformamide (2 ml) was added triethylamine (0.389 ml, 2.78 mmol) at room temperature, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was poured to water, and the precipitated solid was separated by filtration, which was recrystallized from a mixed solvent of ethyl acetate and tetrahydrofuran to give 97.0 mg (36.9%) of the desired product.

Provenance & Evidence