Water → N-1,2-Benzisoxazol-3-yl-4-[3-(phenoxymethyl)-1,2,4-thiadiazol-5-yl]piperazine-1-carboxamide

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Reaction Steps

To a solution of 5-chloro-3-(phenoxymethyl)-1,2,4-thiadiazole (126 mg, 0.555 mmol) and N-1,2-benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate (200 mg, 0.555 mmol) in N,N-dimethylformamide (2 ml) was added triethylamine (0.389 ml, 2.78 mmol) at room temperature, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was poured to water, and the precipitated solid was separated by filtration, which was recrystallized from a mixed solvent of ethyl acetate and tetrahydrofuran to give 151 mg (61.7%) of the desired product.

Provenance & Evidence