Water → HCID 68779631, compound

Participants

Reaction Steps

To a solution of 1-benzyl-4-(5-chloro-1,2,4-thiadiazol-3-yl)piperazine (500 mg, 1.70 mmol) and N-1,2-benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate (612 mg, 1.70 mmol) in N,N-dimethylformamide (5 ml) was added triethylamine (1.18 ml, 8.50 mmol) at room temperature, and the mixture was stirred at room temperature for 0.5 hour. The reaction mixture was poured to water and extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was recrystallized from a mixed solvent of ethyl acetate and hexane to give 347 mg (40.5%) of the desired product.

Provenance & Evidence