Hydrochloric Acid → 1-(4-Phenyl-1,3-thiazol-2-yl)piperazine dihydrochloride

Participants

Reaction Steps

To a solution of tert-butyl 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxylate (1.25 g, 3.62 mmol) in ethyl acetate (20 ml) was added a solution of 4 N hydrogen chloride in ethyl acetate (20 ml), and the mixture was stirred at room temperature for 1 hour. To the reaction mixture was added diethyl ether (30 ml), and the desired product as a solid was separated by filtration, which was washed with diethyl ether to yield 1.06 g (92.2%) of the desired product.

Provenance & Evidence