4-Chlorophenyl Isocyanate → HCID 15979117, compound

Participants

Reaction Steps

To a solvent of 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine (200 mg, 0.812 mmol) and triethylamine (0.113 ml, 0.812 mmol) in tetrahydrofuran (2 ml) was added 4-chlorophenyl isocyanate (0.188 mg, 1.22 mmol), and the mixture was stirred at room temperature for 1 hour. The solvent was distilled off under reduced pressure, and the residue was recrystallized from a mixed solvent of hexane and ethyl acetate to give 310 mg (95.4%) of the desired product as a solid.

Provenance & Evidence