反应详情

Seed crystals were obtained as follows. N-{2-[4-((R)-2-hydroxy-2-phenylethylamino)phenyl]ethyl}-(R)-2-hydroxy-2-(3-formamido-4-benzyloxyphenyl)ethylamine (96.1 mg, 0.18 mmol) was dissolved in 2-propanol (2.2 mL) with warming. A solution of hydrochloric acid in dioxane (4 M, 45 μL, 0.18 mmol) was added. At the end of the addition the majority of material was present as a gum which was stirred at room temperature overnight. The solids were collected by filtration, washed with 2-propanol (3×1 mL) and dried by suction on the filter to give the title compound as a colorless solid (69.5 mg, 69%). 1H NMR in accord with structure (400 MHz, DMSO-d6).

1. customSeed crystals were obtained
2. temperaturewith warming
3. additionAt the end of the addition the majority of material
4. filtrationThe solids were collected by filtration
5. washwashed with 2-propanol (3×1 mL)
6. customdried by suction on the
7. filtrationfilter