Dimethyl Sulfoxide → HCID 68779567, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine (492 mg, 2.00 mmol), bis(2,2,2-trichloroethyl) (6-fluoro-1,2-benzisoxazol-3-yl)imidodicarbonate (502 mg, 1.00 mmol), diisopropylethylamine (0.174 ml, 1.00 mmol) and dimethyl sulfoxide (5 ml) was stirred at 70° C. for 5 hours. The reaction mixture was poured to water and extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was recrystallized from a mixed solvent of tetrahydrofuran and ethyl acetate to yield 136 mg (32.1%) of the desired product.

Provenance & Evidence