Water → HCID 68777834, compound

Participants

Reaction Steps

A mixed solution of 2,2,2-trichloroethyl 1H-benzimidazol-2-ylcarbamate (228 mg, 0.738 mmol), 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine (200 mg, 0.812 mmol) and diisopropylethylamine (0.129 ml, 0.738 mmol) in dimethyl sulfoxide (2.5 ml) was stirred at 70° C. for 3.5 hours. Water was poured to the reaction mixture, and the resulting solution was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column-chromatography (hexane:ethyl acetate=2:8) and recrystallized from a mixed solvent of hexane and tetrahydrofuran to give 35.6 mg (11.9%) of the desired product as a solid.

Provenance & Evidence