Hydrochloric Acid → HCID 68776966, compound

Participants

Reaction Steps

To a solution of 4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-pyridin-3-ylpiperazine-1-carboxamide (1.37 g, 3.73 mmol) in tetrahydrofuran (500 ml) was added a solution of 4 N hydrogen chloride in ethyl acetate (100 ml) at room temperature, and the mixture was stirred at room temperature for 5 hours. The solvent was distilled off under reduced pressure, and the residue was recrystallized from a mixed solvent of diethyl ether and methanol to give 1.38 g (92.1%) of the desired product as a solid. mp 204-205° C.

Provenance & Evidence