Hydrochloric Acid → HCID 68776405, compound

Participants

Reaction Steps

To a solution of tert-butyl [1-(5-{4-[(1,2-benzisoxazol-3-ylamino)carbonyl]piperazin-1-yl}-1,2,4-thiadiazol-3-yl)piperidin-4-yl]carbamate (200 mg, 0.378 mmol) in tetrahydrofuran (10 ml) and methanol (10 ml) was added a solution of 4 N hydrogen chloride in ethyl acetate (10 ml), and the mixture was stirred at room temperature for 5 hours. The solvent was distilled off under reduced pressure, and the residue was recrystallized from a mixed solvent of methanol and diethyl ether to give 181 mg (95.5%) of the desired product as a solid.

Provenance & Evidence