Hydrochloric Acid → HCID 68777860, compound

Participants

Reaction Steps

A solution of tert-butyl {2-[4-(5-{4-[(1,2-benzisoxazol-3-ylamino)carbonyl]piperazin-1-yl}-1,2,4-thiadiazol-3-yl)piperazin-1-yl]-2-oxoethyl}carbamate (70.0 mg, 0.122 mmol) and a solution of 2 N hydrogen chloride in methanol (5 ml) in tetrahydrofuran (5 ml) was stirred at room temperature for 12 hours. The solvent was distilled off under reduced pressure, and the residue was recrystallized from a mixed solvent of methanol and diethyl ether to give 60.0 mg (90.4%) of the desired product as a solid.

Provenance & Evidence