Water → HCID 86625489, compound

Participants

Reaction Steps

To a solution of 6-(4-methylpiperazin-1-yl)pyridine-3-amine (1.00 g, 5.20 mmol) and pyridine (0.509 ml, 6.24 mmol) in tetrahydrofuran (17 ml) was added, under ice-cooling, 2,2,2-trichloroethyl chloroformate (0.509 ml, 6.24 mmol), and the mixture was stirred at room temperature for 1 hour and half. Water was poured to the reaction mixture, and the resulting solution was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. Hexane was poured to the residue, and 349 mg (18.2%) of the desired product as a solid was separated by filtration.

Provenance & Evidence