2-Methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine hydrochloride → 2-Methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine

HRID 2263051Notes

Reaction equation

HRID 2263051 reaction equation
Cl.[CH3:2][CH:3]1[CH2:8][NH:7][CH2:6][CH2:5][N:4]1[C:9]1[S:13][N:12]=[C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:10]=1>[OH-].[Na+]>[CH3:2][CH:3]1[CH2:8][NH:7][CH2:6][CH2:5][N:4]1[C:9]1[S:13][N:12]=[C:11]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:10]=1

Participants

3

Reactant 1

HCID 687774352-Methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine hydrochloride

Product 1

HCID 687761702-Methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazineYield 100.1%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To 2-methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine hydrochloride (500 mg, 1.68 mmol) was added an aqueous 1N sodium hydroxide solution (10 ml) and the mixture was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (438 mg, 100%) as oil.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. dry with materialThe extract was dried over anhydrous magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-6971592717bf4aa88bc8b51c68a39626
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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