反应详情

A solution of ethyl 4-(4-phenyl-2-thienyl)piperazine-1-carboxylate (350 mg, 1.11 mmol), an aqueous 8N sodium hydroxide solution (5 ml) and ethanol (10 ml) was stirred at 100° C. for 3 hours, and the solvent was distilled off under reduced pressure. The residue was poured into water and the mixture was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (240 mg, 88.9%) as an oil.

1. distillationthe solvent was distilled off under reduced pressure
2. additionThe residue was poured into water
3. extractionthe mixture was extracted with chloroform
4. dry with materialThe extract was dried over anhydrous magnesium sulfate
5. distillationthe solvent was distilled off under reduced pressure