Dimethyl Sulfoxide → HCID 86625491, compound

Participants

Reaction Steps

A solution of 1-(tert-butoxycarbonyl)piperazine (5.00 g, 26.8 mmol), 2,2,2-trichloroethyl (3,4-dimethylisoxazol-5-yl)carbamate (3.85 g, 13.4 mmol), disopropylethylamine (2.33 ml, 13.4 mmol) and dimethylsulfoxide (50 ml) was stirred at 70° C. for 2 hours, the reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of ethyl acetate and hexane to obtain the desired product (1.80 g, 41.4%) as a solid.

Provenance & Evidence