Dimethyl Sulfoxide → HCID 11689174, compound

Participants

Reaction Steps

A solution of 2,2,2-trichloroethyl pyridazin-3-ylcarbamate (200 mg, 0.793 mmol), 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine (182 mg, 0.739 mmol), diisopropylethylamine (0.129 ml, 0.739 mmol) and dimethylsulfoxide (3 ml) was stirred at 70° C. for 12 hours, the reaction mixture was poured into water and a solid was collected by filtration. This was recrystallized from ethyl acetate to obtain the desired product (117 mg, 43.0%) as a solid. mp 185-186° C.

Provenance & Evidence