Dimethyl Sulfoxide → HCID 68777445, compound

Participants

Reaction Steps

A solution of 2,2,2-trichloroethyl pyrimidin-5-ylcarbamate (263 mg, 0.972 mmol), 1-(4-phenyl-1,3-thiazol-2-yl)piperazine (238 mg, 0.972 mmol), diisopropylethylamine (0.169 ml, 0.972 mmol) and dimethylsulfoxide (3 ml) was stirred at 70° C. for 12 hours, the reaction mixture was poured into water and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was recrystallized from ethyl acetate to obtain the desired product (97.4 mg, 27.4%) as a solid.

Provenance & Evidence