Dimethyl Sulfoxide → HCID 11559660, compound

Participants

Reaction Steps

A solution of 2,2,2-trichloroethyl pyrazin-2-ylcarbamate (200 mg, 0.545 mmol), 1-(4-phenyl-1,3-thiazol-2-yl)piperazine (181 mg, 0.739 mmol), diisopropylethylamine (0.129 ml, 0.739 mmol) and dimethylsulfoxide (4 ml) was stirred at 70° C. for 12 hours, the reaction mixture was poured into water and a solid was collected by filtration and washed with water. This was recrystallized from a mixed solvent of hexane and ethyl acetate to obtain the desired product (190 mg, 95.4%) as a solid. mp 134-135° C.

Provenance & Evidence