Dimethyl Sulfoxide → HCID 68777308, compound

Participants

Reaction Steps

A solution of 2,2,2-trichloroethyl [3-(acetylamino)phenyl]carbamate (200 mg, 0.614 mmol), 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine (151 mg, 0.614 mmol), diisopropylethylamine (0.107 ml, 0.614 mmol) and dimethylsulfoxide (4 ml) was stirred at 70° C. for 12 hours, the reaction mixture was poured into water and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate) to obtain the desired product. This was recrystallized from a mixed solvent of ethyl acetate and hexane to obtain the desired product (107 mg, 41.3%) as a solid.

Provenance & Evidence