4-(4-Phenyl-1,3-thiazol-2-yl)piperidine dihydrochloride → 4-Phenyl-2-(piperidin-4-yl)thiazole

HRID 2263125Notes

Reaction equation

HRID 2263125 reaction equation
Cl.Cl.[C:3]1([C:9]2[N:10]=[C:11]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[S:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>[OH-].[Na+]>[C:3]1([C:9]2[N:10]=[C:11]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[S:12][CH:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 509882684-(4-Phenyl-1,3-thiazol-2-yl)piperidine dihydrochloride

Product 1

HCID 242618344-Phenyl-2-(piperidin-4-yl)thiazoleYield 100.4%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To 4-(4-phenyl-1,3-thiazol-2-yl)piperidine dihydrochloride (530 mg, 1.88 mmol) was added an aqueous 1N sodium hydroxide solution (10 ml) and the mixture was extracted with chloroform (50 ml). The extract was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (461 mg, 100%) as an oil.

Workup

  1. extractionthe mixture was extracted with chloroform (50 ml)
  2. dry with materialThe extract was dried over anhydrous magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-f1e7f5c584574bfd9a6eb52560f02719
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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