Water → HCID 86245081, compound

Participants

Reaction Steps

To a solution of 5-methylisoxazole-3-amine (1.00 g, 10.2 mmol) and pyridine (0.998 ml, 12.2 mmol) in tetrahydrofuran (34 ml) was added 2,2,2-trichloroethyl chloroformate (1.69 ml, 12.2 mmol) with ice-cooling and the mixture was stirred at room temperature for 1 hour. Water was poured into the reaction mixture and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. Hexane was poured to the residue and a solid was collected by filtration to obtain the desired product (2.55 g, 91.4%).

Provenance & Evidence