Bromine → 2-Bromo-2'-fluoroacetophenone

Participants

Reaction Steps

To a solution of 1-(2-fluorophenyl)ethanone (5.00 g, 36.2 mmol) in diethyl ether (100 ml) was slowly added dropwise bromine (5.78 g, 36.2 mmol), and the mixture was stirred at room temperature for 4 hours. The reaction solution was distilled off under reduced pressure to give the desired product (5.89 g, 74.9%) as an oil.

Provenance & Evidence