Water → Thiocyanic acid, 2-(2-fluorophenyl)-2-oxoethyl ester

HRID 2263175Notes

Reaction equation

HRID 2263175 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11])=[O:4].[S-:12][C:13]#[N:14].[K+].O>C(O)C>[F:11][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:3](=[O:4])[CH2:2][S:12][C:13]#[N:14]

Participants

5

Reactant 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 27374492-Bromo-2'-fluoroacetophenone

Product 1

HCID 18526224Thiocyanic acid, 2-(2-fluorophenyl)-2-oxoethyl esterYield 95.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-bromo-1-(2-fluorophenyl)ethanone (5.00 g, 23.0 mmol) and potassium thiocyanate (2.24 g, 23.0 mmol) in ethanol (50 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (60 ml) was poured into the reaction solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the desired product (4.29 g, 95.5%) as a solid.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-96725ae2fc564cedb3af24ca0bc94c03
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

Loading…