Water → 2-(3-Fluorophenyl)-2-oxoethyl thiocyanate

HRID 2263179Notes

Reaction equation

HRID 2263179 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[CH:6]=1)=[O:4].[S-:12][C:13]#[N:14].[K+].O>C(O)C>[F:11][C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][S:12][C:13]#[N:14])[CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 27374513-Fluorophenacyl bromide

Product 1

HCID 862451472-(3-Fluorophenyl)-2-oxoethyl thiocyanateYield 74.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-bromo-1-(3-fluorophenyl)ethanone (1.00 g, 4.61 mmol) and potassium thiocyanate (448 mg, 4.61 mmol) in ethanol (10 ml) was stirred at 80° C. for 3 hours. After cooling to room temperature, water (12 ml) was poured into the reaction solution, and a crystal was separated by filtration, which was washed with 50% aqueous ethanol solution to give the desired product (668 mg, 74.3%) as a solid.

Workup

  1. customa crystal was separated by filtration, which
  2. washwas washed with 50% aqueous ethanol solution

Sources & evidence

ORD record
ord-06e82e5a2751446dbfc875069a39dd64
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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