Water → 2-(4-Fluorophenyl)-2-oxoethyl thiocyanate

HRID 2263184Notes

Reaction equation

HRID 2263184 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[S-:12][C:13]#[N:14].[K+].O>C(O)C>[F:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][S:12][C:13]#[N:14])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 516872Potassium thiocyanate

Product 1

HCID 41989922-(4-Fluorophenyl)-2-oxoethyl thiocyanateYield 82.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-bromo-1-(4-fluorophenyl)ethanone (5.00 g, 23.0 mmol) and potassium thiocyanate (2.24 g, 23.0 mmol) in ethanol (50 ml) was stirred at 80° C. for 3 hours. After cooling to room temperature, water (60 ml) was poured into the reaction solution, and a crystal was separated by filtration, which was washed with 50% aqueous ethanol solution to give the desired product (3.71 g, 82.5%) as a solid.

Workup

  1. customa crystal was separated by filtration, which
  2. washwas washed with 50% aqueous ethanol solution

Sources & evidence

ORD record
ord-cf6002745db34f7fbd217ec0cf98e789
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

Loading…