Sodium Hydroxide → HCID 68778455, compound

HRID 2263209Notes

Reaction equation

HRID 2263209 reaction equation
Cl.Cl.[F:3][C:4]1[CH:5]=[C:6]([C:10]2[N:11]=[C:12]([N:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[S:13][CH:14]=2)[CH:7]=[CH:8][CH:9]=1.[OH-].[Na+]>O>[F:3][C:4]1[CH:5]=[C:6]([C:10]2[N:11]=[C:12]([N:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[S:13][CH:14]=2)[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68778580HCID 68778580, compound

Product 1

HCID 68778455HCID 68778455, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-[4-(3-Fluorophenyl)-1,3-thiazol-2-yl]piperidine dihydrochloride (1.00 g, 2.99 mmol) was dissolved in water. The solution was neutralized with 1N aqueous sodium hydroxide solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over magnesium sulfate anhydrous, and the solvent distilled off under reduced pressure to give the desired product (780 mg, 99.4%) as an oil.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over magnesium sulfate anhydrous
  4. distillationthe solvent distilled off under reduced pressure

Sources & evidence

ORD record
ord-288c91ad2ea84839b87fa470db726fde
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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