Dimethyl Sulfoxide → 4-[3-(2-fluorophenyl)-1,2,4-thiadiazol-5-yl]-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperazine-1-carboxamide

Participants

Reaction Steps

A solution of bis(2,2,2-trichloroethyl) [4-(2-oxopyrrolidin-1-yl)phenyl]imidodicarbonate (200 mg, 0.379 mmol), 1-[3-(2-fluorophenyl)-1,2,4-thiadiazol-5-yl]piperazine (196 mg, 0.742 mmol), diisopropylethylamine (0.132 ml, 0.758 mmol) and dimethyl sulfoxide (4 ml) was stirred at 70° C. for 24 hours, and the reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was recrystallized from ethyl acetate to give 25.3 mg (14.3%) of the desired product as a solid.

Provenance & Evidence