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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2263236Generated: October 25, 2026

Methanol → N-(4-Aminophenyl)propanamide

https://huagongshe.com/reaction/2263236

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantN-(4-Nitrophenyl)propionamideHCID 3627923—
CatalystPalladiumHCID 23938—
SolventTetrahydrofuranHCID 8028—
ProductN-(4-Aminophenyl)propanamideHCID 31434294.8%

Reaction Steps

A mixture of N-(4-nitrophenyl)propanamide (10 g, 51.5 mmol), 10% palladium on carbon (1 g), methanol (500 ml) and tetrahydrofuran (100 ml) was stirred under hydrogen atmosphere for 12 hours, insoluble substances were removed by filtration, and the filtrate was concentrated to give 8.00 g (94.8%) of the desired product as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07851473B2
Source datasetuspto-grants-2010_12
ORD IDord-1440103e8f404a808306c6bce395f453
Source noteuspto-grants-2010_12