Bromine → 2-Bromo-1-(2,3-difluorophenyl)ethanone

HRID 2263258Notes

Reaction equation

HRID 2263258 reaction equation
[Br:1]Br.[F:3][C:4]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:5]=1[C:11](=[O:13])[CH3:12]>C(OCC)C>[Br:1][CH2:12][C:11]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([F:10])[C:4]=1[F:3])=[O:13]

Participants

4

Reactant 2

HCID 24408BromineHCID 5195502',3'-Difluoroacetophenone

Product 1

HCID 27831672-Bromo-1-(2,3-difluorophenyl)ethanoneYield 99.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Bromine (4.96 g, 31.1 mmol) was slowly added dropwise to a solution of 1-(2,3-difluorophenyl)ethanone (4.85 g, 31.1 mmol) in diethyl ether (100 ml), and the mixture was stirred at room temperature for 5 hours. The reaction mixture was distilled off under reduced pressure to give 7.29 g (99.9%) of the desired product as an oil.

Workup

  1. distillationThe reaction mixture was distilled off under reduced pressure

Sources & evidence

ORD record
ord-a9930742dd3f4d73bfeec6441ac181e8
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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