Water → 2-(2,3-Difluorophenyl)-2-oxoethyl thiocyanate

HRID 2263259Notes

Reaction equation

HRID 2263259 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[F:12])=[O:4].[S-:13][C:14]#[N:15].[K+].O>C(O)C>[F:12][C:6]1[C:7]([F:11])=[CH:8][CH:9]=[CH:10][C:5]=1[C:3](=[O:4])[CH2:2][S:13][C:14]#[N:15]

Participants

5

Reactant 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 27831672-Bromo-1-(2,3-difluorophenyl)ethanone

Product 1

HCID 862452192-(2,3-Difluorophenyl)-2-oxoethyl thiocyanateYield 86.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-bromo-1-(2,3-difluorophenyl)ethanone (7.20 g, 30.6 mmol) and potassium thiocyanate (3.01 g, 30.6 mmol) in ethanol (70 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (85 ml) was poured to the reaction mixture, and the mixture was extracted with chloroform. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give 5.67 g (86.8%) of the desired product as an oil.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-fc97b6f15bea4180b1361cc5f42b5b86
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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