1-(3-Chlorophenyl)ethanone → 2-Bromo-3'-chloroacetophenone

HRID 2263270Notes

Reaction equation

HRID 2263270 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:5]=[C:6]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1>C(OCC)C>[Br:1][CH2:11][C:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([Cl:3])[CH:5]=1)=[O:12]

Participants

4

Reactant 2

HCID 149331-(3-Chlorophenyl)ethanoneHCID 24408Bromine

Product 1

HCID 387382-Bromo-3'-chloroacetophenone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Bromine (5.17 g, 32.3 mmol) was slowly added dropwise to a solution of 1-(3-chlorophenyl)ethanone (5.00 g, 32.3 mmol) in diethyl ether (100 ml), and the mixture was stirred at room temperature for 4 hours. The reaction mixture was distilled off under reduced pressure, and the desired product was obtained quantitatively as an oil.

Workup

  1. distillationThe reaction mixture was distilled off under reduced pressure

Sources & evidence

ORD record
ord-38fd4934a4b2485ab48a887a6ee3f805
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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