Bromine → 3-(2-Bromoacetyl)benzonitrile

HRID 2263276Notes

Reaction equation

HRID 2263276 reaction equation
[Br:1]Br.[C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])(=[O:5])[CH3:4]>C(OCC)C>[Br:1][CH2:4][C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])=[O:5]

Participants

4

Reactant 2

HCID 24408BromineHCID 802223-Acetylbenzonitrile

Product 1

HCID 27358673-(2-Bromoacetyl)benzonitrile

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Bromine (5.50 g, 34.4 mmol) was slowly added dropwise to a solution of 3-acetylbenzonitrile (5.00 g, 34.4 mmol) in diethyl ether (100 ml), and the mixture was stirred at room temperature for 4 hours. The reaction mixture was distilled off under reduced pressure to give the desired product as an oil.

Workup

  1. distillationThe reaction mixture was distilled off under reduced pressure

Sources & evidence

ORD record
ord-04a42132691a43d1ad2149c4488c5cc7
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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