Hydrochloric Acid → Phthalylglycine aldehyde

Participants

Reaction Steps

A 6 N aqueous hydrochloric acid solution (20 ml) was added to a solution of 2-(2,2-diethoxyethyl)-1H-isoindol-1,3(2H)-dione (1.0 g, 3.80 mmol) in acetone (20 ml), the mixture was stirred at room temperature for 6 hours, and the solvent was distilled off under reduced pressure. A saturated sodium hydrogen carbonate aqueous solution was added to the residue, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the desired product as an oil.

Provenance & Evidence