Thionyl Chloride → 2-(1,2,3-Thiadiazol-5-yl)-1H-isoindole-1,3(2H)-dione

Participants

Reaction Steps

Ethyl (2E)-2-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethylidene]hydrazinecarboxylate (612 mg, 2.22 mmol) was slowly added to thionyl chloride (1.5 ml), and the mixture was stirred for 1 day. Crystals were collected by filtration and washed with ethyl acetate to give 308 mg (59.9%) of the desired product as a solid.

Provenance & Evidence