Hydrochloric Acid → HCID 61781041, compound

Participants

Reaction Steps

A 4 N solution (50 ml) of hydrogen chloride in ethyl acetate was added to a solution of tert-butyl 4-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate (2.63 g, 7.00 mmol) in ethyl acetate (50 ml), the mixture was stirred at room temperature for 20 hours, and the solvent was distilled off under reduced pressure. The residue was dissolved in water, neutralized with a 1 N sodium hydroxide aqueous solution, and extracted with chloroform. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give 1.43 g (74.3%) of the desired product as a solid.

Provenance & Evidence