Water → 2-(3-Methylphenyl)-2-oxoethyl thiocyanate

HRID 2263302Notes

Reaction equation

HRID 2263302 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)=[O:4].[S-:12][C:13]#[N:14].[K+].O>C(O)C>[CH3:11][C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][S:12][C:13]#[N:14])[CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 100361292-Bromo-1-(3-methylphenyl)ethan-1-one

Product 1

HCID 862450512-(3-Methylphenyl)-2-oxoethyl thiocyanateYield 84.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-bromo-1-(3-methylphenyl)ethanone (3.03 g, 14.2 mmol) and potassium thiocyanate (1.45 g, 14.2 mmol) in ethanol (30 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (30 ml) was poured to the reaction mixture, and crystals were collected by filtration and washed with water to give 2.29 mg (84.2%) of the desired product as a solid.

Workup

  1. filtrationwere collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-702c6d3889fa427e96ab2b32edb0b657
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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