Bromine → 2-Bromo-2'-chloroacetophenone

HRID 2263312Notes

Reaction equation

HRID 2263312 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:12])[CH3:11]>C(OCC)C>[Br:1][CH2:11][C:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[Cl:3])=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 72864Ethanone, 1-(2-chlorophenyl)-

Product 1

HCID 27357852-Bromo-2'-chloroacetophenone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Bromine (5.18 g, 32.3 mmol) was slowly added dropwise to a solution of 1-[2-chlorophenyl]ethanone (5.00 g, 32.3 mmol) in diethyl ether (100 ml), and the mixture was stirred at room temperature for 4 hours. The reaction mixture was distilled off under reduced pressure to give 2-bromo-1-(2-chlorophenyl)ethanone as an oil quantitatively.

Workup

  1. distillationThe reaction mixture was distilled off under reduced pressure

Sources & evidence

ORD record
ord-c601a593f9e04c22a87ac105ea85332f
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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