Water → 2-(2-Chlorophenyl)-2-oxoethyl thiocyanate

HRID 2263313Notes

Reaction equation

HRID 2263313 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])=[O:4].[S-:12][C:13]#[N:14].[K+].O>C(O)C>[Cl:11][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:3](=[O:4])[CH2:2][S:12][C:13]#[N:14]

Participants

5

Reactant 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 27357852-Bromo-2'-chloroacetophenone

Product 1

HCID 242137572-(2-Chlorophenyl)-2-oxoethyl thiocyanateYield 75.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-bromo-1-(2-chlorophenyl)ethanone (7.55 g, 32.3 mmol) and potassium thiocyanate (3.14 g, 32.3 mmol) in ethanol (70 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (70 ml) was poured to the reaction mixture, and crystals were collected by filtration and washed with water to give 5.15 g (75.3%) of the desired product as a solid.

Workup

  1. filtrationwere collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-bf9526e7ef8447539045f76933e9ab5f
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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