HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Bromo-4-(2,3-dichlorophenyl)-1,3-thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Reactant | 2-(2,3-Dichlorophenyl)-2-oxoethyl thiocyanate | HCID 86245058 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-4-(2,3-dichlorophenyl)-1,3-thiazole | HCID 53440971 | 94.6% |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
A 25% hydrogen bromide/acetic acid (30 ml) solution was added to a solution of 2-(2,3-dichlorophenyl)-2-oxoethyl thiocyanate (3.10 g, 12.6 mmol) in acetic acid (30 ml), and the mixture was stirred at 130° C. for 2 hours. Water (60 ml) was poured to the reaction mixture, and crystals were collected by filtration and washed with water to give 3.68 g (94.6%) of the desired product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851473B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-44f17f47f3a84a26bb838905abf9e97c |
| Source note | uspto-grants-2010_12 |