HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 226332Generated: October 27, 2026
Hydrochloric Acid → ethyl (2E)-3-[6-(4-piperidylamino)-3-pyridyl]acrylate dihydrochloride
https://huagongshe.com/reaction/226332
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl 4-({5-[(1E)-3-ethoxy-3-oxo-1-propen-1-yl]-2-pyridyl}amino)-1-piperidinecarboxylate | HCID 68960290 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | ethyl (2E)-3-[6-(4-piperidylamino)-3-pyridyl]acrylate dihydrochloride | HCID 86603643 | — |
Reaction Steps
To a solution of tert-butyl 4-({5-[(1E)-3-ethoxy-3-oxo-1-propen-1-yl]-2-pyridyl}amino)-1-piperidinecarboxylate (2.8 g) in EtOH (20 ml) was added 4N HCl in dioxane (18.6 ml), the mixture was stirred at 23° C. for 30 minutes. The precipitate was collected, washed with IPE, dried under reduced pressure to give ethyl (2E)-3-[6-(4-piperidylamino)-3-pyridyl]acrylate dihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07557127B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-68e6077fe54d44ff84b0e8f53fe3baec |
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| Source note | uspto-grants-2009_07 |
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