HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Bromo-4-(2,4-dichlorophenyl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-(2,4-Dichlorophenyl)-2-oxoethyl thiocyanate | HCID 14397604 | — |
| Reactant | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-4-(2,4-dichlorophenyl)thiazole | HCID 68780305 | 92% |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
A 25% hydrogen bromide/acetic acid (60 ml) solution was added to a solution of 2-(2,4-dichlorophenyl)-2-oxoethyl thiocyanate (5.97 g, 24.3 mmol) in acetic acid (60 ml), and the mixture was stirred at 130° C. for 2 hours. Water (120 ml) was poured to the reaction mixture, and crystals were collected by filtration and washed with water to give 6.89 g (92.0%) of the desired product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07851473B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-e21efa94b19a4b9ba091eb2f0a3e0433 |
| Source note | uspto-grants-2010_12 |