Water → HCID 178517449, compound

HRID 2263355Notes

Reaction equation

HRID 2263355 reaction equation
O=[C:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][S:4][C:5]#[N:6].O.S(=O)(=O)(O)[OH:15]>C(O)(=O)C>[C:7]1([C:2]2[N:6]=[C:5]([OH:15])[S:4][CH:3]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 219693Phenacyl thiocyanate

Product 1

HCID 178517449HCID 178517449, compoundYield 84.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixed solution of 2-oxo-2-phenylethyl thiocyanate (5.67 g, 32.0 mmol), water (3.2 ml), concentrated sulfuric acid (0.832 ml) and acetic acid (26 ml) was stirred at 130° C. for 2 hours and at room temperature for 2 hours. A formed precipitate was collected by filtration and washed with water to give 4.78 g (84.3%) of the desired product.

Workup

  1. filtrationA formed precipitate was collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-c2c674fe9df84e358642efaac43b937c
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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