関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 4-Oxazolin-2-one, 4-phenyl- | HCID 118669 | — |
| 生成物 | 2-Chloro-4-phenyloxazole | HCID 21408261 | 15.7% |
反応手順
To a solution of 4-phenyl-1,3-oxazol-2(3H)-one (1.00 g, 62.0 mmol) in phosphorus oxychloride (18 ml) was added pyridine (0.974 ml, 12.0 mmol), and the mixture was stirred at 100° C. for 1 hour and 20 minutes. The solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane: ethyl acetate=9:1) to give 176 mg (15.7%) of the desired product as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07851473B2 |
|---|
| 出典データセット | uspto-grants-2010_12 |
|---|
| ORD ID | ord-5090c86d84594faf94a90ff756da590d |
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| 出典メモ | uspto-grants-2010_12 |
|---|
