HCID 59594756, compound → HCID 59594668, compound

Participants

Reaction Conditions

Reaction Steps

2.73 g 4-Difluoromethyl-2-(4-methoxy-phenyl)-thiazole-5-carboxylic acid were dissolved in 30 ml tetrahydrofuran. 23 ml of a one molar solution of borane tetrahydrofuran complex were added and the reaction mixture stirred at 40° C. for three hours. The cooled reaction mixture was poured on ice water and extracted three times with portions of 100 ml ethyl acetate. The combined organic layers were dried over MgSO4. Then the solvent was removed in vacuo to obtain 2.70 g [4-difluoromethyl-2-(4-methoxy-phenyl)-thiazol-5-yl]-methanol.

Provenance & Evidence