HCID 136149956, compound → HCID 136149961, compound

Participants

Reaction Steps

To a mixture of 20 mg of 3-{2-fluoro-4-[4-hydroxymethyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-4H-[1,2,4]oxadiazol-5-one in 10 mL of chloroform was added 23 mg of manganese dioxide. After stirring at room temperature overnight, the reaction mixture was filtered through celite and washed with dichloromethane/methanol. The filtrate was concentrated under reduced pressure to give 200 mg of 5-[3-fluoro-4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenoxymethyl]-2-(4-trifluoromethyl-phenyl)-thiazole-4-carbaldehyde as a beige solid.

Provenance & Evidence