Ethyl Acetate → HCID 59594672, compound

Participants

Reaction Steps

To a solution of 2.63 g 2-chloro-4-hydroxy-benzonitrile in 25 ml dimethylformamide were added 4.0 g 5-chloromethyl-4-methyl-2-[2-(4-trifluoromethyl-phenyl)-ethyl]-oxazole and 8.58 g cesium carbonate. The mixture was stirred at room temperature overnight. Then 150 ml of ethyl acetate were added, the mixture washed with 40 ml water and brine and then dried over MgSO4. The solvent was removed in vacuo. The resulting crude material was purified by RP-HPLC to obtain 3.0 g 2-chloro-4-{4-methyl-2-[2-(4-trifluoromethyl-phenyl)-ethyl]-oxazol-5-ylmethoxy}-benzonitrile.

Provenance & Evidence