Dichloromethane → HCID 59296137, compound

Participants

Reaction Steps

4.1 g 4-[4-Hydroxymethyl-2-(4-methoxy-phenyl)-oxazol-5-ylmethoxy]-2-methyl-benzonitrile were dissolved in 90 ml dichloromethane and cooled in an ice bath. 2.44 ml triethylamine were added, followed by the addition of 1.08 ml methanesulfonylchloride. The ice bath was removed and the resulting mixture stirred at room temperature over night. The reaction mixture was then washed with water and brine, dried over MgSO4 and the solvent removed in vacuo to obtain 2.5 g of 5-chloromethyl-2-(4-methoxy-phenyl)-4-(tetrahydro-pyran-2-yloxymethyl)-oxazole as an oil which was used without further purification.

Provenance & Evidence