Hydrochloric Acid → HCID 11651949, compound

Participants

Reaction Steps

A mixture of 4-(2,3-dichlorophenyl)-1-propyl-1,2,3,6-tetrahydropyridine (0.4 g, 1.48 mmol), platinum oxide (0.05 g) and hydrochloric acid (0.1 ml, conc) in methanol (30 ml) was hydrogenated at 50 psi for 1 h under hydrogen gas. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated and evaporated to dryness to give 0.4 g of the title compound as the hydrochloric acid salt (87%). Recrystallization from ethanol/diethyl ether: M.p. 265-267° C. MS m/z (relative intensity, 70 eV) 271 (M+, 4), 243 (66), 242 (bp), 164 (9) 115 (17).

Provenance & Evidence