HCID 23156218, compound → HCID 23156222, compound

Participants

Reaction Steps

A solution of 54.00 g of 5-bromo-3-(3-methoxyprop-1-ynyl)-1-methyl-1H-indazole in 1700 ml of methanol is admixed at room temperature with 20.58 g of 10% Pd/C. The mixture is hydrogenated over 1.5 hours and clarified by filtration, and the filtrate is concentrated by evaporation. The title compound is obtained as a yellowish oil from the residue by means of flash chromatography (SiO2 60 F). Rf=0.56 (1:1 EtOAc-heptane). Rt=4.37 (gradient I).

Provenance & Evidence